Formulation: A solid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C9H7D4N3O
Formula Weight: 181,2
Shelf life (days): 1460
CAS Number: 66148-19-4
Notes: N′-Nitrosonornicotine-d4 is intended for use as an internal standard for the quantification of N′-nitrosonornicotine (Item No. 34120) by GC- or LC-MS. N′-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.{45975} It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N′-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N′-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.{61431}