Target: N-terminal Arginylation
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: 4A9
Immunogen: Synthetic N-terminal arginylated peptide conjugated to KLH
Purification: Protein G Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Specific for N-terminal arginine next to glutamic acid. Does not detect N-terminal arginine next to aspartic acid or internal arginine residues.
Cellular Localization: Endoplasmic Reticulum
Scientific Background: Protein arginylation is the post-translational addition of arginine to proteins by arginyltransferase ATE1. Arginylation of proteins has been found to play an essential role in physiological pathways during embryogenesis and adulthood (1). Arginylation has also been shown to regulate cell stress responses, including ER stress, cytosolic misfolded proteins, and heat stress (2).
References: 1. Saha S. and Kashina A. (2011) Dev Biol. 385(1): 1-8.2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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