Target: NALCN
Conjugate: APC
Product Type: Monoclonal
Clone Number: N187/7 (Formerly sold as S187-7)
Immunogen: Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Swiss-Prot: Q6Q760
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~200kDa.
Cellular Localization: Membrane
Scientific Background: NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
References: 1. Lee, J.H., Cribbs, L.L. and Perez-Reyes, E. (1999)FEBS Lett. 445: 231-236.2. Lu, B., Su, Y., Das, S., Liu, J., Xia, J. and Ren, D. (2007) Cell 129: 371-383.3. Jospin, M., et al. (2007) Curr. Biol. 17: 1595-1600.4. Gaultier, C. and Gallego, J. (2008) Appl. Physiol. 104: 1522-1530.5. Yeh, E., et al. (2008) PLoS Biol. 6: e55.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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