Target: Nav1.8
Conjugate: PerCP
Product Type: Monoclonal
Clone Number: S134
Immunogen: Fusion protein amino acids 1724-1956 of rat Nav1.8
Swiss-Prot: Q62968
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~220kDa. No cross reactivity against other Nav channels.
Cellular Localization: Membrane
Scientific Background: Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
References: 1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58.2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212.3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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