Formulation: A crystalline solid
Formal Name: S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid
Purity: ≥98%
Formula Markup: C20H26N2O2S2
Formula Weight: 390,6
Shelf life (days): 1460
CAS Number: 848354-66-5
Notes: NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.{41830} It increases acetylation of histone H4 and α-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM).{41831,41832} NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-α, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.{41830}
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