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Encompassing Amino Acids: 395-489
Application: Useful for SDS-PAGE.
Background: NcoR2 (nuclear receptor co-repressor 2), also known as SMRT (silencing mediator for retinoid or thyroid-hormone receptor), is a transcriptional co-regulatory protein that can recruit histone deacetylases to promoter regions. It is expressed widely in humans and its role in the regulation of different genes makes it critical for the development and maintenance of tissues. NcoR2 has been linked to multiple cancer types, acting as an oncogene or tumor suppressor depending on context. For instance, in breast cancer, it can lead to high levels of cyclin D and cell proliferation. It has also been implicated in treatment resistance, by inhibiting cytotoxic stress response and anti-tumor immunity by regulating HDAC3 (histone deacetylase 3). Targeting NcoR2-HDAC3 using an AAV NcoR2-HDAC3 competitor resulted in better responses to chemo- and immune checkpoint therapy, opening new therapeutic windows in oncology.
Description: Recombinant human NcoR2 (nuclear receptor co-repressor 2), encompassing amino acids 395-489. This construct contains an N-terminal GST-tag. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol
Genbank: NM_006312
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-Tag
Uniprot: Q9Y618
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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