Formulation: A crystalline solid
Formal Name: 9-β-D-ribofuranosyl-9H-purine
Purity: ≥98%
Formula Markup: C10H12N4O4
Formula Weight: 252,2
Shelf life (days): 1460
CAS Number: 550-33-4
Notes: Nebularine is a purine ribonucleoside and an adenosine analog that has been found in L. nebularis and has diverse biological activities.{52765,52766,52767,52768,23726} It reduces herpes simplex virus 1 (HSV-1) viral plaque formation in Vero cells (IC50 = 0.6 µM) and is active against M. phlei, M. avium, M. tuberculosis, and B. abortus.{52765,52766} Nebularine (10 and 100 µM) is cytotoxic to COS-7 cells and induces pyknosis in mouse sarcoma 180 cells and mouse embryonic skin explants in a concentration-dependent manner.{52767,52768} It inhibits root growth of wheat seedlings when used at concentrations ranging from 0.1 to 2 mM.{52766} Nebularine also inhibits adenosine deaminase (Ki = 16 µM).{23726}
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