NF2 / Merlin Polyclonal Antibody, Rabbit

Abbreviation: NF2

Target Synonym: ACN;BANF;Merlin;Neurofibromin 2;neurofibromin 2 (merlin);NF2;SCH;Schwannomerlin;Schwannomin

Conjugation: Unconjugated

UNIProt ID: P35240

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Concentration: 2.2mg/ml

Immunogen: Recombinant Human NF2 protein expressed by E.coli.

Dilution: WB 1:500-1:1000

• SKU: ELSE-AB-40642-50
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-40642-50
• Package Unit: 50 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Host: Rabbit