Formulation: A lyophilized powder
Formal Name: L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid
Purity: ≥95%
Formula Markup: C75H118N20O22S
Formula Weight: 1683,9
Shelf life (days): 1460
CAS Number: 249537-73-3
Notes: NFAT inhibitor is a peptide inhibitor of the transcription factor nuclear factor of activated T cells (NFAT).{7199} It binds to the NFAT recognition site on the protein phosphatase calcineurin (IC50 = 25 pM) but does not inhibit calcineurin phosphatase activity when used at a concentration of 100 µM.{21639,7199} NFAT inhibitor inhibits the dephosphorylation of NFAT in HEK293T lysates expressing NFAT1, -2, or -4 in a concentration-dependent manner.{7199} It inhibits NFAT activation in RAW 264.7 macrophages, EA.hy926 endothelial cells, and isolated mouse thoracic aorta vascular smooth muscle cells (VSMCs; IC50s = 29.1, 30.2, and 45.7 µM, respectively, in reporter assays).{68194}
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