Notes: NFAT inhibitor (cell-permeable) is a cell-permeable form of NFAT inhibitor (Item No. 13855), an inhibitor of calcineurin-nuclear factor of activated T cells (NFAT) signaling.{69110} It inhibits the production of IL-12p40 and nitric oxide (NO) in LPS- and IFN-γ-induced mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. NFAT inhibitor (cell-permeable) (1 mg/kg) prevents increases in kidney weight and urine albumin levels in a db/db mouse model of diabetic nephropathy.{69111} It improves fracture healing in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 100 µg/kg for 16 weeks post-fracture.{69112} NFAT inhibitor (cell-permeable) (1 mg/kg) decreases disease severity in IL-10 knockout mice in a model of colitis induced by piroxicam (Item No. 13368).{69110}