Product Type: Inducer
CAS No.: 50-65-7
MolecularFormula: C13H8Cl2N2O4
Molecular Weight: 327,12
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble to 25 mM in ethanol and to 10 mM in DMSO
Appearance: Pale yellow solid
PubChem CID: 4477
Scientific Background: Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes.
References: 1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
