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Encompassing Amino Acids: 2-1036 (end)
Description: Human NLR Family Pyrin Domain Containing 3 (NLRP3), also known as NALP3, Cold Autoinflammatory Syndrome 1 Protein (CIAS1), cryopyrin and PYPAF1 (Genbank Accession No. NM_004895), a.a. 2-1036(end), with N-terminal His-FLAG-tag and with GKTïƒ AAA mutations at 231-233, expressed in a HEK293 expression system. MW = 120 kDa.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 10 ng/µL Flag peptide, 3 mM DTT, and 20% glycerol
Genbank: NM_004895
Storage Stability: At least 6 months at -80°C. Protein may be diluted to ≥ 100 µg/ml in PBS + glycerol and stored at -80°C.
Tags: N-terminal His-FLAG-tag
Uniprot: Q96P20
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kummer, J.A., J. Histochem. Cytochem., 2007 May; 55(5):443-52.2. Manji, G.A., J. Biol. Chem. 2002 Mar 29; 277(13):11570-5. Application Reference(s):1. Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease (2017)2. BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination (2017)
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