NM-3, CAS 181427-78-1

Formulation: A solid

Formal Name: 8-hydroxy-6-methoxy-α-methyl-1-oxo-1H-2-benzopyran-3-acetic acid

Purity: ≥98%

Formula Markup: C13H12O6

Formula Weight: 264,2

Shelf life (days): 365

CAS Number: 181427-78-1

Notes: NM-3 is a synthetic isocoumarin and an inhibitor of angiogenesis.{66550} It inhibits S180 cell-induced angiogenesis in an implanted dorsal air sac in mice when administered at doses of 1, 3, and 10 mg/kg. NM-3 (10, 20, and 40 mg/kg) induces intratumoral apoptosis and reduces tumor microvascular density in an SGC-7901 gastric cancer mouse xenograft model.{66551} It decreases renal levels of VEGF, TGF-β1, and angiopoietin-2 (ANG-2) and renal fibrosis in the db/db transgenic mouse model of diabetes when administered at a dose of 100 mg/kg.{66552}

• SKU: CAY40219-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40219-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK