Product Type: Inhibitor
CAS No.: 31430-18-9
MolecularFormula: C14H11N3O3S
Molecular Weight: 301,3
Source: Synthetic
Purity: ≥98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (10 mg/ml, warm)
Appearance: White to off-white powder.
PubChem CID: 4122
Scientific Background: Nocodazole also known as Oncodazole. It is an antimitotic agent, associated with the activity of depolymerization of the microtubules (1). Nocadozole has high affinity with Tubulin but little is known on the mechanism of binding. Studies have shown that Nocadozole binds differently to the various α/β isotypes of Tubulin. By measuring the dissociation constants, with the given binding sites, a novel approach of therapeutic agents is under study (2).
References: 1. Vasquez RJ., Howell B., Yvon AM., Wadsworth P., Cassimus L. (1997) Mol Biol Cell. 8(6): 973-985.2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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