Product Type: Inhibitor
CAS No.: 6833-84-7
MolecularFormula: C40H64O12
Molecular Weight: 736,93
Source: Synthetic
Purity: >98% (TLC)
Solubility: Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water.
Appearance: White to off-White solid
PubChem CID: 72519
Scientific Background: Nonactin also known as Polynanctin, Werramycin A is a member of the family of cyclic ionophores. It has a high selectivity for ammonium ions and for this reason is also known as “ammonium ionophore”. It was first isolated by Corbaz et al. in 1955 from bacterial strains (1). To understand the required stereochemistry for an efficient bacterial and ion binding, various isothermal calorimetric measurements were performed with K+, Na+ and NH4+. Nonactin is active against a range of gram positive organisms and has a high selectivity for K+ (2).
References: 1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48.2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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