Formulation: A solid
Formal Name: 4,8,13,17-tetramethyl-2E,4E,6E,8E,10E,12E,14E,16E,18E-eicosanonaenedioic acid, hydrate
Purity: ≥70%
Formula Markup: C24H28O4 • XH2O
Formula Weight: 380,5
Shelf life (days): 730
Notes: Norbixin is a carotenoid that has been found in B. orellana and has diverse biological activities.{66574,66575,66572,66573} It binds to peroxisome proliferator-activated receptor γ (PPARγ) in a cell-free assay (Ki = 1.15 µM).{66574} Norbixin (47.7 mg/kg) attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome. It decreases serum levels of oxidized LDL and aortic protein oxidation, as well as reduces atherosclerotic area, in a rabbit model of cholesterol-induced atherosclerosis.{66575} Norbixin (0.1 and 1 mg/kg per day) reduces mercury-induced DNA damage in isolated rat hepatocytes and leukocytes.{66572} It also prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).{66573}
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