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Encompassing Amino Acids: 26-530
Application: Useful for SDS-PAGE.
Background: Notch2 (neurogenic locus notch homolog protein 2) is a type I transmembrane protein of the Notch family. It is involved in the development of the vascular network, brain, kidneys, liver, T and B lymphocytes. The protein undergoes cleavage in the trans-golgi network, forming a heterodimer. Binding of Notch2 to its ligands of the Delta/Serrate/LAG-2 family leads to its cleavage by ADAM (A disintegrin and metaloprotease) proteins. NICD (notch intracellular domain) is released and translocated to the nucleus, where it can form complexes with DNA-binding proteins and lead to transcription of target genes. Mutations in this protein can result in Hadju-Cheney syndrome. Overexpression of Notch2 is found in several cancer types, such as LSCC (laryngeal squamous cell carcinoma) and B cell malignancies. The use of inhibitors to target this protein is being studied with the goal of understanding better the role of this protein and potentially target it in cancer therapy.
Description: Recombinant human Notch2 (neurogenic locus notch homolog protein 2), encompassing amino acids 26-530 (extracellular domain). This construct contains a C-terminal Fc domain from IgG1 followed by an Avi-tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_024408.4
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™
Uniprot: Q04721
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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