Conjugation: HRP: Horseradish Peroxidase
Description of Target: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2
Key Reference: Zandi,P.P., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) In press
Molecular Weight: 28kDa
Peptide Sequence: Synthetic peptide located within the following region:
KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: E3 SUMO-protein ligase NSE2
Protein Size: 247
Purification: Affinity Purified
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