Target: NuaK1 (pThr211)
Conjugate: Unconjugated
Product Type: Polyclonal
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr211 of human NuaK1 (AA208-214)
Swiss-Prot: O60285
Purification: Peptide Affinity Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Specificity: Detects 74.305 kDa.
Cellular Localization: Nucleus,Cytoplasm
Tissue Specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.
Scientific Background: NUAK1 is a protein-serine/threonine kinase. Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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