Formulation: A solid
Formal Name: 2S-amino-5,5-difluoro-4,4-dimethyl-pentanoic acid
Purity: ≥95%
Formula Markup: C7H13F2NO2
Formula Weight: 181,2
Shelf life (days): 1460
CAS Number: 2095886-80-7
Notes: NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator.{58992} It binds to sestrin 2 (Kd = 1.49 µM) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 µM. NV-5138 (40, 80, or 160 mg/kg) reduces immobility time in the forced swim test and latency to feed in the novelty-suppressed feeding test, indicating antidepressant- and anxiolytic-like activity, respectively, in rats, effects that can be reversed by the mTORC1 inhibitor rapamycin (Item No. 13346).{58993} It also reverses behavioral and synaptic deficits in a rat model of chronic stress-induced depression.
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