Formulation: Lyophilized from sterile PBS, pH 7.4
Purity: ≥95% as determined by SDS-PAGE
Shelf life (days): 365
Notes: Osteomodulin (OMD), is a class II keratan sulfate small leucine-rich proteoglycan (SLRP) with roles in bone mineralization, cell adhesion, tooth formation, and the regulation of collagen fibrils.{64867,64868} It is primarily expressed in mineralized tissues, including bones and teeth, but is also expressed in articular chondrocytes and fibrochondrocytes.{64867} OMD binds to bone morphogenetic protein 2 (BMP2), promoting SMAD signaling and osteogenesis. It also binds to type I collagen and induces morphology and size changes in collagen fibrils, indicating a role in the regulation of extracellular matrix components during bone formation.{64868} Increased plasma levels of OMD are associated with cardiac calcification in patients with chronic kidney disease (CKD).{64870} Serum levels of OMD are increased and positively correlated with plaque calcification in patients with carotid atherosclerosis. Serum levels of OMD are also decreased in patients with osteoarthritis.{64869} Cayman’s Osteomodulin (human, recombinant) protein consists of 412 amino acids, has a calculated molecular weight of 48.6 kDa, and a predicted N-terminus of Gln21 after signal peptide cleavage.
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