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Applications: This enzyme cleaves K48- and K63- linked ubiquitin chains in vitro.
Background: Otubain 1 is a member of the OTU (ovarian tumor) class of ubiquitin isopeptidases. It was originally identified as a protein capable of binding ubiquitin aldehyde.Researchers have shown that it is able to cleave K48-linked ubiquitin chains in vitro.Otubain 1 has been shown to be involved in T cell function and is a substrate for Yersinia protein kinase.
Description: Human Otub1 recombinant protein, with His-tag, expressed in E. coli.
Format: Aqueous buffer solution
Purity: ≥95% by SDS-PAGE
Storage Stability: Store at or below -80°C. Stable as supplied for up to 1 year when stored dessicated at -80°C.
Tags: His-tag
Uniprot: Q96FW1
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Juris, S.J., et al. FEBS Lett. 2006. 581(1):179-183.
2. Soares, L., et al. Nat. Immunol. 2004. 51(1):45-54.
3. Balakirev, M. et al. EMBO Rep. 2003. 4(5): p517-522.