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Applications: OX40 binding molecule (such as anti-OX40 antibody) screening and profiling in a cellular context
Background: OX40 (CD134) is a co-stimulatory receptor expressed on the surface of CD4+ and CD8+ T cells 24 to 48 hours after activation. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T cell survival and increases cytokine production. OX40 has been shown to activate NF-κB-mediated memory cell generation through its interaction with adaptor proteins TRAF2 and TRAF5. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response.
Description: Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).
Format: Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened using the metabolite-based Mycoplasma Detection Kit (Biotool #B3903) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store in liquid nitrogen.
Supplied As: Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
References: 1. Rogers, P.R. et al., Immunity. 2001; 15(3): 445-455.2. Ito, T. et al., J. Exp. Med. 2005; 202(9): 1213-1223.
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