p-methyl-N-salicyloyl Tryptamine, CAS 1371564-45-2

Formulation: A solid

Formal Name: 2-hydroxy-N-[2-(1H-indol-3-yl)ethyl]-4-methyl-benzamide

Purity: ≥98%

Formula Markup: C18H18N2O2

Formula Weight: 294,4

Shelf life (days): 1095

CAS Number: 1371564-45-2

Notes: p-methyl-N-salicyloyl Tryptamine is a neuroprotective agent and derivative of N-salicyloyl tryptamine.{69402} It reduces LPS-induced nitric oxide (NO) production in C6 rat glioma cells and BV-2 mouse microglia (IC50s = 7.48 and 4.94 µM, respectively). It also reduces LPS-induced production of TNF-α and prostaglandin E2 (PGE2; Item No. 14010) and increases production of IL-10 in BV-2 microglia when used at a concentration of 40 µM. In vivo, p-methyl-N-salicyloyl tryptamine (25-100 mg/kg) decreases cortical and hippocampal amyloid-β (Aβ) plaque formation and neuronal pyroptosis, as well as improves spatial learning and memory, in a mouse model of Aβ-induced Alzheimer’s disease.{69404}

• SKU: CAY38958-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38958-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK