Target: p53.
Conjugate: FITC.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the C-terminal of human tumor protein p53.
Swiss-Prot: P04637.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
Cellular Localization: Cytoplasm, Nucleus, PML body, Endoplasmic Reticulum, Mitochondrion matrix.
Scientific Background: The p53 protein (tumor protein 53 or TP53) is a DNA-binding cell cycle-regulating transcription factor that governs cell division and the fine balance between cell death and cell survival (1). P53 plays a critical role in tumor suppression and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman." This also refers to its role in conserving stability by preventing genome mutation (2). Defects in p53 are linked to >50% of human cancers, and restoring p53 function to these cancer cells can induce growth arrest and apoptosis (3). When p53 has been damaged, it can also lead to autoimmune disorders (4, 5).
References: 1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16(2): 133-9.2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics.3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774.4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8.5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48(1): 41-4.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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