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Encompassing Amino Acids: 2-394(end)
Applications: Useful for SDS-PAGE.
Background: p53 is a transcription factor and tumor suppressor very frequently mutated in human cancer and often termed "guardian of the genome". Activated by DNA damage, oxidative stress, or deregulated oncogene expression, p53 binds to a specific site in the promoter region of target genes and leads to the transcriptional activation of downstream genes involved in DNA repair, cell cycle arrest, senescence, and apoptosis. Inactivation of p53 promotes genome instability and directly contributes to cell transformation.
Description: Recombinant human p53 (cellular tumor antigen p53), encompassing amino acids 2-394(end). This construct contains an N-terminal FLAG-tag followed by a Precission cleavage site. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT, and variable FLAG peptide
Genbank: NM_000546
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal FLAG-Tag
Uniprot: P04637
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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