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Encompassing Amino Acids: 300-591
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: PAK4 is a recently identified member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK4 belongs to the Group II PAKs which also includes PAK5 and PAK6. PAK4 has been shown to regulate cell morphology and cytoskeletal organization in mammalian cells.
Description: Human PAK4 (GenBank Accession No. BC002921), a.a. 300-591, MW=33.3 kDa, expressed in E. coli.
Format: Aqueous buffer solution
Formulation: 25 mM Tris-HCl, pH 8, 150 mM NaCl, 10% glycerol, 5 mM DTT
Genbank: BC002921
Purity: ≥95%
Storage Stability: At least 6 months at -80°C.
Tags: none
Uniprot: O96013
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kimmelman,A.C., et al., Proc. Natl. Acad. Sci. U.S.A. 105 (49), 19372-19377 (2008).
2. Menzel,N., et al., Biochem. J. 416 (2), 231-241 (2008).
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