Formulation: A solution in water
Formal Name: 3,3′,3′′,3′′′-(1,2-ethanediyldinitrilo)tetrakis[N-(2-aminoethyl)-propanamide
Formula Markup: C22H48N10O4
Formula Weight: 516,7
Shelf life (days): 730
CAS Number: 155773-72-1
Notes: PAMAM dendrimer G0.0 amine (PAMAM G0.0) is the polyamidoamine (PAMAM) core with amine termini on which other PAMAM dendrimers are synthesized.{51536} It is approximately 15 Å in diameter and has 4 surface groups. PAMAM G0.0 is an antagonist for the pore-forming channels anthrax toxin protective antigen 63 (PA63; IC50 = 231 nM) and C. botulinum C2 toxin subunit C2IIa (IC50 = 940 nM) in lipid membranes.{67569} It reduces C2 toxin-induced death in HeLa cells when used at concentrations of 10 and 20 µM. PAMAM G0.0 is a chelator of nickel.{67570} In complex with polysulfone membrane-bound chitosan, PAMAM G0.0 selectively captures and stores carbon dioxide (CO2) over nitrogen (N2) in a gas-feed system.{67571} PAMAM G0.0 has been used in the synthesis of PAMAM dendrimer G0.5 carboxylate (Item No. 39104) and PAMAM dendrimer G1.0 amine (Item No. 39054).{67570}
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