Formulation: A solution in water
Formal Name: 2-propenoic acid, polymer with 1,2-ethanediamine, methyl ester
Formula Markup: [NH2(CH2)2NH2]:(G=2);dendri PAMAM(NH2)16
Formula Weight: 3256,2
Shelf life (days): 730
CAS Number: 26937-01-9
Notes: PAMAM dendrimer G2.0 amine (PAMAM G2.0) is a polyamidoamine (PAMAM) dendrimer with amine termini.{51536} It is approximately 29 Å in diameter and has 16 surface groups. PAMAM G2.0 (15 mg/ml) in combination with erythromycin (Item No. 16486) enhances the solubility and antibacterial activity of erythromycin against S. aureus.{65905} It increases the cell growth rate of HEK293T and HeLa cells when used at concentrations ranging from 100 to 500 nM but is cytotoxic to the same cells when used at concentrations greater than or equal to 700 nM.{65903} In vivo, PAMAM G2.0 when administered in combination with fluorescein isothiocyanate-labeled dextran enhances its nasal absorption in rats.{65904}
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