PAMAM Dendrimer G3.0 Amidoethanol (water solution)

Formulation: A solution in water

Formula Markup: [NH2(CH2)2NH2]:(G=3);dendri PAMAM(NHCH2CH2OH)32

Formula Weight: 6940,4

Shelf life (days): 730

Notes: PAMAM dendrimer G3.0 amidoethanol (PAMAM G3.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini.{67576} It is approximately 30 Å in diameter in PBS and has 32 surface groups. PAMAM G3.0 amidoethanol is an antagonist for the pore-forming channels anthrax protective antigen 63 (PA63) in lipid membranes (IC50 = 44.9 nM).{67569} It inhibits aggregation of amylin containing a serine-to-glycine substitution at position 20 (amylinS20G) in a concentration-dependent manner and amylinS20G-induced toxicity in MIN6-K8 and NIT-1 pancreatic β-cells at 6 µM.{65920} Topical application of PAMAM G3.0 amidoethanol (1 mg/ml) encapsulating the synthetic glucocorticoid dexamethasone (Item No. 11015) increases the levels of dexamethasone in the sclera, conjunctiva, and cornea in isolated rabbit eyes.{65921} It reduces tail growth in C. riparius larvae and induces DNA damage in a comet assay using C. riparius larval homogenates when used at concentrations of 10 or 100 ppm.{65922}

• SKU: CAY39112-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39112-500
• Package Unit: 500 mg
• Quantity Unit: STK