PAMAM Dendrimer G3.0 Amine (water solution), CAS 153891-46-4

Formulation: A solution in water

Formula Markup: [NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32

Formula Weight: 6908,8

Shelf life (days): 730

CAS Number: 153891-46-4

Notes: PAMAM dendrimer G3.0 amine (PAMAM G3.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.{51536,51551} It is approximately 36 Å in diameter and has 32 surface groups.{51536} It is cytotoxic to DU145 cells (IC50 = ~13.42 µM) and toxic to zebrafish embryos, inducing mortality 72 hours post-fertilization when used at a concentration of 0.2 µM.{51552} Liposomes coated with PAMAM G3.0 and encapsulating the isoquinoline alkaloid berberine (Item No. 10006427) and the anthraquinone chrysophanol (Item No. 19870) reduce hydrogen peroxide-induced production of reactive oxygen species (ROS) in ARPE-19 retinal epithelial cells and protect against retinal damage in a rat model of photooxidation-induced age-related macular degeneration (AMD).{51551}

• SKU: CAY39073-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39073-500
• Package Unit: 500 mg
• Quantity Unit: STK