Formulation: A solution in water
Formula Markup: [NH2(CH2)2NH2]:(G=4);dendri PAMAM(NHCH2CH2OH)64
Formula Weight: 14277,2
Shelf life (days): 730
Notes: PAMAM dendrimer G4.0 amidoethanol (PAMAM G4.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vivo.{66590} It is approximately 45 Å in diameter and has 64 surface groups.{66591} Conjugates of PAMAM G4.0 amidoethanol and the synthetic glucocorticoid methylprednisolone (Item No. 15013) decrease ovalbumin-induced increases in the number of eosinophils in bronchoalveolar lavage fluid (BALF) and lung tissue to a greater extent than methylprednisolone alone in a mouse model of lung inflammation.{66590} PAMAM G4.0 amidoethanol is toxic to the cyanobacteria Anabaena and green alga C. reinhardtii (EC90s = 5.13 and 1.02 mg/L, respectively) and induces the formation of reactive oxygen species (ROS) in both.{72180} Unlike PAMAM G3.0, -G4.0, -G5.0, and -G6.0-NH2, PAMAM G4.0 amidoethanol is unable to transfect cells.{66592}
English
Deutsch
