Formulation: A solution in water
Formula Markup: [NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
Formula Weight: 14214,2
Shelf life (days): 730
CAS Number: 163442-67-9
Notes: PAMAM dendrimer G4.0 amine (PAMAM G4.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.{51536,72161} It is approximately 45 Å in diameter and has 64 surface groups.{51536} It inhibits fibril formation by α-synuclein in a cell-free assay when used at concentrations of 1 and 2 µM.{72162} PAMAM G4.0 is active against E. coli (IC50 = 3.8 µg/ml) and toxic to zebrafish embryos, inducing mortality at 120 hours post-fertilization when used at concentrations ranging from 0.5 to 20 µM.{51536,51537} PAMAM G4.0 (100 and 300 mg/kg) in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice without inducing gastrointestinal toxicity.{51539} PEG-modified PAMAM G4.0 in complex with folic acid (Item No. 20515), 5-fluorouracil (5-FU; Item No. 14416), and the imaging agent technetium-99m (PEG-PAMAM G4-FA-5FU-99mTc) localizes to the tumor, as well as the liver and spleen, in a 4T1 murine mammary tumor model.{72161}
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