Formulation: A solution in water
Formula Weight: 20615
Shelf life (days): 730
Notes: PAMAM dendrimer G4.0 succinamic acid (PAMAM G4.0-SAH) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini that has been used as a drug delivery system in vitro and in vivo.{68603},{68604} It is approximately 45 Å in diameter in PBS and has 64 surface groups.{67576},{67552} PAMAM G4.0-SAH (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in infected Vero cells.{67552} It is active against S. aureus.{51558} Lipid-dendrimer hybrid nanoparticles containing PAMAM G4.0-SAH and encapsulating the glycopeptide antibiotic vancomycin (Item No. 15327) are active against S. aureus and methicillin-resistant S. aureus (MRSA).{68603} In vivo, PAMAM G4.0-SAH conjugated to the monosaccharide sialic acid, also known as N-acetylneuraminic acid (Neu5Ac), prevents infection by the influenza A subtype H3N2 in a mouse model of pneumonitis when administered at a dose of 9 µg/g.{68604}
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