PAMAM Dendrimer G4.5 Carboxylate (sodium salt) (water solution), CAS 202009-66-3

Formulation: A solution in water

Formula Markup: [NH2(CH2)2NH2]:(G=4.5);dendri PAMAM(NHCH2CH2COONa)128

Formula Weight: 26251,9

Shelf life (days): 730

CAS Number: 202009-66-3

Notes: PAMAM dendrimer G4.5 carboxylate (PAMAM G4.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system.{67597} It is approximately 87.9 Å in diameter in water and has 96 surface groups.{67554} Unlike the amine-terminated PAMAM G5.0 (Item No. 39075), it does not rupture bilayer lipid membranes when used at a concentration of 50 µM.{67598} PAMAM G4.5 carboxylate disulfur-linked aggregates (10 µg/ml) encapsulating the phenol ferulic acid (Item No. 19871) and the mitotic inhibitor paclitaxel (Item No. 10461) induce apoptosis and decrease the mitochondrial membrane potential in multidrug-resistant KB-8-5 epidermal carcinoma cells.{67597} Complexes of PAMAM G4.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 620 nM).{67596} A fluorescently labeled form of PAMAM G4.5 carboxylate selectively accumulates in tumors and kidneys over liver, spleen, heart, and lungs in a 4T1 murine mammary carcinoma model.{67599}

• SKU: CAY39109-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39109-1
• Package Unit: 1 g
• Quantity Unit: STK