Products from BPS Bioscience require a minimum order value above 400€Encompassing Amino Acids: 2-583
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Enzyme reaction is conducted usingBPS's PARP2 Assay Kit (Catalog #80552) at room temperature for 1 hour.
Description: Human PARP2 (GenBank Accession No. NM_005484), a.a. 2-583 with N-terminal GST-tag, MW = 92 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 16 mMglutathione, 20% glycerol, and 3 mM DTT.
Genbank: NM_005484
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q9UGN5
Unit Definition: One unit of PARP incorporates 100 pmoles of poly(ADP) in 1 minute from NAD into the acid-insoluble form.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Jha, R., et al., Fertil. Steril. 91 (3), 782-790 (2009).
2. Quenet, D., et al., FASEB J. 22 (11), 3853- 3865 (2008).Application References:
1.
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency (2013)
2. Fragment-based ligand design of novel potent inhibitors of tankyrases (2013)
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