Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cGMP signaling. Mouse PDE5A, also known as cGMP-inhibited phosphodiesterase, has been implicated in cardiovascular function and fertility. The Mouse PDE5A1 Assay Kit is designed for identification of inhibitors of Mouse PDE5A1 using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by Mouse PDE5A1 to the binding agent.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Supplied As: The Mouse PDE5A1 Assay Kit comes in a convenient 96-well format, with purified Mouse PDE5A1 enzyme, fluorescently labeled substrate (cGMP), binding agent, and PDE assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Tommpo, et al., Adv Neurobiol. 2017;17:103-131.2. Clapcote SJ, et al., NeuroReport. 2007; Nov; 18(17):1841-1844.
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