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Encompassing Amino Acids: 550-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes (1). PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase (2).
Description: Recombinant human PDGFRα (550-end), GenBank accession number NM_006206, with an N-terminal GST-tag, expressed by baculovirus in Sf9 insect cells.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_006206
Host Cell Line: Sf9 cells
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: P16234
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Floege, J. et al. J Am Soc Nephrol. 1998 Feb,9(2):211-23.
2. Kumagai, S. et al. Tohoku J Exp Med. 2001 Sep,195(1):21-33.
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