Calculated MW: 302
Positive Control: The peptide used to product this antibody is available for purchase (Catalog Number:GTX26037-PEP).
Form: Liquid
Buffer (with preservative): TBS, 0.5% BSA, 0.02% Sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene.
Uniprot ID: O15018
Antigen Species: Human
Immunogen: Peptide with sequence PITQDNAVLHLPLC, from the N Terminus of the protein sequence according to NP_835260.2.
Purification: Purified by ammonium sulphate precipitation followed by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: PDZ domain containing 2
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