Clone Name: 5B10
Application Note: IHC-P: 1:20. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 61
Specificity/Sensitivity: This antibofy shows cross-reactivity with smooth muscle and differentiated epithelium.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
Uniprot ID: P14222
Antigen Species: Human
Immunogen: Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: perforin 1
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