Product Type: Inducer
CAS No.: 1716-12-7
MolecularFormula: C10H11NaO2
Molecular Weight: 186,18
Source: Synthetic
Purity: >98%
Solubility: Soluble to 1100 mM in water and 100 mM in DMSO
Appearance: White solid
PubChem CID: 5258
Scientific Background: Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
References: 1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54.2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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