Product Type: Inhibitor
CAS No.: 344458-15-7
MolecularFormula: C17H17N3O2•HCL•H2O
Molecular Weight: 331,8
Source: Synthetic
Purity: ≥98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
Appearance: White to yellow solid.
PubChem CID: 4858
Scientific Background: PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).
References: 1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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