Conjugation: HRP: Horseradish Peroxidase
Description of Target: PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO; EC 1.4.3.5).[supplied by OMIM].
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PNPO
Key Reference: Song,H., Schizophr. Res. 97 (1-3), 264-270 (2007)
Molecular Weight: 29kDa
Peptide Sequence: Synthetic peptide located within the following region:
PMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Pyridoxine-5'-phosphate oxidase
Protein Size: 261
Purification: Affinity Purified
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