Immunogen: Synthetic human proinsulin
Concentration: n/a
Storage buffer: Lyophilized; reconstitute in 100 µl dist. water
Additional info: Insulin is produced by the B-cells of the pancreatic islets and by insulin-producing islet cell tumors.
Absorption with 10-100 ug proinsulin per ml diluted antiserum inactivates the antiserum, while C-peptide and insulin only partly reduce staining.
Positive control: formalin-fixed paraffin sections of human pancreas.
References: Kohnert, K. D. et al. Regul. Pept.1999; 82: 71–9/Ahrén, B. et al. Pancreas 1999; 18: 75–83/Al-Amily, I. et al. Pflugers.Arch.2019; 471:633-645