Immunogen: Substance P (code 7451, Peninsula, USA), conjugated to BSA
Concentration: n/a
Storage buffer: Lyophilized; reconstitute in 100 µl dist. water
Additional info: Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, broncho-constriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.Absorption with 10-100 ug SP and NKA per ml diluted antiserum abolishes the staining while GRP and NKB do not.Positive control: frozen sections of rat colon.
References: Kressel, M.et al. J. Comp. Neurol. 1999;412: 161–172 /Witt, M.et al. Histochem. Cell Biol.1998; 109: 281–291/Shahbazi, F. et al. Am. J. Physiol. - Regul. Integr. Comp. Physiol. 1998;275: R19–R28
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