Immunogen: Calcitonin gene-related peptide (synthetic, rat, #6006, Peninsula), conjugated to BSA
Concentration: n/a
Storage buffer: Lyophilized; reconstitute in 100 µl dist. water
Additional info: The CGRP-sequence was predicted from the corresponding mRNA. CGRP is present in the C-cells of the thyroid and in nerves, in both brain and periphery, particularly within the sensory system. CGRP is a potent vasodilator, probably involved in neurogenic inflammation. Medullary carcinomas of the thyroid contain large amounts of CGRP. Absorption with 10-100 ug CGRP per ml diluted antiserum abolishes the staining while calcitonin, substance P and Neurokinin A do not. The antiserum cross-reacts with amylin.Positive control: frozen sections of rat colon.
References: Suzuki, N. et al. Neuroscience 1989;30: 595–604 /Grunditz, T. et al. Endocrinology 1986;119:2313-2324 /Luts, L.et al. Regul. Pept.1994;50: 147–158
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