Immunogen: Purified porcine VIP
Concentration: n/a
Storage buffer: Lyophilized; reconstitute in 100 µl dist. water
Additional info: VIP is localized in nerve fibers of the central and peripheral nervous system, and is probably acting as a neurotransmitter. Smooth muscle relaxation, vasodilation and secretion from exocrine glands are some of the effects of VIP. The Verner-Morrison or Watery Diarrhea Hypokaliemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors. These VIP-producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.
Absorption with 10-100 ug immunogen per ml diluted antiserum abolishes the staining, while PHI, secretin, glucagon, GIP, and CCK do not.Positive control: formalin-fixed paraffin sections of cat ileum.
References: Ny, L. et al. Histochem. J. 1994;26: 721–733 /Tagliafierro, G.et al. Cell Tissue Res. 1988;253: 23–8 /Karila, P. et al. Cell 1997; 287:525-33
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