Application Note: WB: 1:500-1:2000. IHC-P: 1:100-1:500. ELISA: 1:5000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 52
Form: Liquid
Buffer (with preservative): 0.01M TBS, 1% BSA, 50% Glycerol, 0.03% Proclin300.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Uniprot ID: Q07869
Antigen Species: Human
Immunogen: KLH conjugated synthetic phosphopeptide derived from human PPAR alpha around the phosphorylation site of ser12.
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: peroxisome proliferator activated receptor alpha
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