Formulation: A solution in methyl acetate
Formal Name: bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-(propylazanediyl)dipropionate
Purity: ≥98%
Formula Markup: C37H73NO4S4
Formula Weight: 724,2
Shelf life (days): 365
Notes: PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.{67652} LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.
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