Conjugation: HRP: Horseradish Peroxidase
Description of Target: PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
Key Reference: Rogozin,I.B., (2007) Leuk. Res. 31 (11), 1521-1528
Molecular Weight: 56kDa
Peptide Sequence: Synthetic peptide located within the following region:
MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Melanoma antigen preferentially expressed in tumors
Protein Size: 509
Purification: Affinity Purified
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